New gene therapy combined with RNAi technology

Researchers at the University of California, Los Angeles and the California Institute of Technology have developed a new gene therapy method to prevent HIV from entering human cells. This technology provides a possible way to treat HIV-infected people, and can be used for any disease caused by genetic dysfunction, including cancer. This article was published in the Proceedings of the National Academy of Sciences on December 13, 2002 in the United States.

The research team discovered a new use of the technology called small interfering RNA (small interfering RNA, siRNA). Specially designed synthetic siRNA as a catalyst can reduce the expression of specific genes and slow down the disease. "Synthetic siRNAs are very powerful tools, but scientists are incapable of inserting them into the immune system in a stable form. You can't just put them in your cells." Irvin SY Chen, director of the AIDS Research Institute at the University of California, Los Angeles Said.

This technology is also meaningful for the treatment of infections, autoimmune diseases and immune diseases. "We can use siRNA to prevent microorganisms from entering the body, or appearing in the wrong place, at the wrong time," Baltimore said. "We can turn off the overproduction of a special hormone. In short, the application of this technology has unlimited possibilities."

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